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found in anxiety disorders only when activated by an immediate stressor. Molecular Genetics Lesch, Bengal, Hells, and Sabol (1996) found an association between a serotonin transporter gene (5-HTTLPR) and the trait of neuroticism, as assessed by three different scales including the NEO N scale and Cloninger s TCI harm avoidance scale. Individuals with either one or two copies of the short form had higher N scores than individuals homozygous for the long variant of the gene. The association was limited to the N factor of the NEO and the harm avoidant factor of the TCI; none of the other factors in these test was associated with the genetic variant. However, in a second study by this group (Hamer, Greenberg, Sabol, & Murphy, 1999) the association of the gene with harm avoidance was weaker, and associations were found with TCI traits of cooperativeness and self-directiveness. Several other studies have not been able to replicate the relationship between the gene variants and N or harm avoidance. This is a common outcome in the hunt for speci c genes associated with personality traits or types of psychopathology, even when studies have adequate power and use good methodology. Population differences may account for some of these failures. Even in the studies that are signi cant the particular gene accounts only for a small portion of the genetic variance. In the Lesch et al. study the 5-HTT polymorphism accounted for 3% to 4% of the total variance for the trait and 7% to 9% of the genetic variance, and 10 to 15 more genes were estimated to be involved. If there is any replication of a gene-trait association, that nding should not be immediately dismissed by subsequent failures of replication, particularly if the nding has a theoretical basis. In this case Cloninger s theory has suggested the involvement of serotonin in harm avoidance. The short form of the gene, which is associated with high neuroticism, reduces serotonin uptake and therefore increases serotonergic transmission. Reduced uptake has been associated with anxiety in animal and human models, but paradoxically the serotonin uptake inhibitors are therapeutic agents in depressive disorders and several forms of anxiety disorders. These drugs could achieve their results through the inhibitory effects of serotonin on other systems such as the noradrenergic ones. Summary A sudden intense surge in anxiety is characterized by arousal of the sympathetic branch of the autonomic nervous system as expressed in elevated heart and breathing rates, blood pressure, sweating, and other signs of activation of this system. This led to the expectation that N or trait
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Perhaps prompted by the apparent lack of good design choices and network tools for scalable general-purpose RM, a trend in reliable multicast has been focusing on adding router support for fast and ef cient loss recovery [39 43]. The key question is what and how much mechanism to introduce into the network layer. Some proposals maintain retransmission soft state or buffer packets in routers. Others support richer multicast forwarding semantics than does IP multicasting.
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1: Preparing Your Installation . . . . . . . . . . . . . . . . . . . . 3
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Figure 11.3. Effect of EHT implantation of the spatial organization of connexin 43 (Cx-43) in rat hearts. The left panel shows an immunoconfocal image from the middle of a rat heart, the right panel from the area of EHT implantation (EHT upper left corner, host myocardium right lower part). Cx-43 is indicated in green, phalloidin-stained actin in red. Note the disorganization of Cx-43 at the implantation site. (See Color Plate 6A.)
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Meanwhile, in nearby northern France and Belgium, groundwater monitoring stations recorded a sudden rise in the water table just before the oods struck. The valley of the River Somme was particularly affected by the oods. Subsequent analysis of the ood hydrograph for the River Somme in the vicinity of Abbeville revealed that the volume of ood water conveyed by the channel far exceeded the total volume of rainfall in the preceding weeks (Mul et al. 2003). Subsequent hydrological analysis resulted in the following explanation: Some of the water which recharges the Chalk aquifer is trapped above the regional water table forming lenses of perched groundwater. Under normal conditions, these lenses drain very slowly. Intense rainfall can trigger a sudden acceleration of the drainage of these lenses. As the water table rises, the lenses are progressively submerged, and the volumes of water that they contain become part of the main saturated zone, owing towards the discharge zones as part of the three-dimensional ow eld. As Mul et al. (2003) conclude: After submersion of these [lenses] in the groundwater, the combined system drains as one linear reservoir, causing a massive groundwater-induced ood. Similar instances of groundwater ooding have been reported from limestone aquifers elsewhere. For instance, in southern Spain, groundwater oods in 1996 97 caused extensive and costly damage to prime agricultural land and rural residences overlying the Sierra Gorda karst aquifer (L pez Chicano et al. 2002). After a prolonged drought which lasted around 5 years, precipitation during the winter of 1995 96 was more than 60% greater than average. The resultant rise in the water table within the Sierra Gorda aquifer was as great as 175 m in places. Although the rains of the following winter were not as intense, because the water table was already very high and there was no moisture de cit in the unsaturated zone, the further rise in the water table led to ooding of large areas on the oor of a large-scale doline feature. Flooding initially took the form of two separate lakes which later coalesced. Although evidence is at present limited to a few case studies, these few relate to limestone
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Different analytical strategies have been exploited in GMO analysis: (1) screening methodology that commonly detects regulatory sequences or marker genes, and which aims to detect the presence or absence of GM-material; (2) GMO identi cation via the identi cation of speci c genes, detection of
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Figure 4-3
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