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1.1. Context of Tissue Engineering In any tissue engineering effort, the preparation of cells is a critical system component along with the biomaterial matrix and bioreactor environment. Cell preparation typically involves the appropriate choice of cell type (e.g., differentiated or progenitor, human or animal), expansion, seeding, and genotypic and phenotypic characterization of cells within the context of the speci c tissue engineering goal (tissue-speci c outcomes). 1.2. ACL Injury and Limitations of Prevalent Treatments The need to explore tissue engineering options for the anterior cruciate ligament (ACL) has arisen from the inability of currently available clinical options to fully restore knee function. Over the last twenty years, orthopedic sports medicine has been faced with continued repair needs associated with tears and ruptures of the ACL, a major cause of athletic disability. Presently, more than 200,000 ACL ruptures occur in the United States each year. Injury to the ACL and the high frequency of subsequent knee instability often result in further damage to the joint, motivating improvements in ACL reconstructive techniques. Currently, autologous tendon grafts harvested at the time of reconstruction are the most widely utilized ACL replacement tissues, but this practice typically results in tendon donor site morbidity. Allograft tendons have gained acceptance because they alleviate donor site morbidity problems associated with autograft harvest, but cost, risk of infection, and disease transmission remain problematic. Synthetic polymers have also been widely used as ligament replacements, including polytetra uorethylene (Gore-tex ), polyester (Dacron ), carbon ber, and polypropylene ligament augmentation devices (LAD). Complications due to stress shielding, particulate debris, and early mechanical failures are commonly associated with these prostheses. 1.3. Tissue Engineering May Be the Solution for ACL Replacement Tissue engineering may potentially provide improved clinical options in orthopedic medicine through the generation of biologically based functional tissues in vitro for transplantation at the time of injury or disease. A tissue-engineered
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7 It is important to note that given the deployment area, the density can be engineered beforehand by simply deploying a suitable number of sensors uniformly at random.
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monitoring its distance to the target. When the distance becomes larger than a certain threshold d, it will be replaced by the node that is closest to the center of the current monitoring region. 13.8.3 Mobicast Protocol for Tracking Mobile Objects One particular application of geocasting is tracking mobile objects. Mobile objects create geocast regions that are time dependent, and data collection is performed by the sensors in the vicinity of a moving object. The sink may collect reports from the sensors in the vicinity of the object, and may send periodic signals to the sensors adjusting the geocasting region, following the trajectory along with the object advances. In mobicast application [45], however, the sensors themselves adjust the geocasting region. Huang, Lu, and Roman [45,46] proposed a mobicast protocol where the nodes that belong to the forward, time-dependent region, or belong or are about to enter the geocast region, retransmit the message. Their algorithm presented in ref. [45] is an improved version of the one in ref. [46]. In their problem formulation, the MC is not used to decide and inform about the geocast region. Instead, the sensors themselves cooperate, follow the movement of an object, and inform the sensors, which are approached by the object, to start monitoring. This is achieved by considering the planar graph of covering sensors, and forwarding messages to the faces of the planar graph in the direction of object movement, with proper timing corresponding to the arrival time of the object at the considered face. This is illustrated in Figure 13.7. Suppose that the rectangle object, shown with dashed lines, moved from the far left and is continuing toward the far right. All faces that the object intersected are traversed by messages from sensors in these faces. They are marked in Figure 13.7 by clockwise arrows along the face edges (following the
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Operation When the first multicast datagram (containing the source net, multicast destination) is received by a router, it will find the source subnet in the linkstate database. A source-rooted multicast tree is built using the Router LSAs and the Network LSAs and the Dykstra algorithm. Once the tree is built, it is pruned using the information from the groupmembership LSAs. Final result of the Dykstra algorithm is the pruned shortest-path tree that is rooted at the source. Based on this, an entry is made in the forwarding cache of the router.
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FIGURE 9.1. Gaussian channel.
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Allport described his solicitation and publication of case studies as the one distinctive contribution that I have made during my term of editorial service (G. W. Allport, 1949, p. 440). He also supported the work of authors such as Jean Evans, a reporter whose case studies appeared rst in the Journal (1948, 1950) and later in a book (1954). In her foreword, Evans expressed her appreciation to Dr. Gordon W. Allport, whose idea it was in the rst place that such a book should be written (p. xvii). Publication Trends Continuing an earlier trend, the number of studies of individuals published both in general psychology journals and in personality journals (the Journal of Abnormal and Social Psychology and Character and Personality) declined during the 1930s and 1940s (G. W. Allport, 1940b; Shermer, 1985). Although early volumes of Character and Personality featured studies using biographical and archival methods (Craik, 1986), this journal was atypical. Founded in 1932 by Robert Saudek, a European graphologist (Roback, 1935), it was originally international in scope and emphasized psychodiagnostics, or character reading based on expressive behavior (G. W. Allport, 1937b), an approach that received little attention from American researchers. Allport was on the editorial board of the journal, which published the studies of several students from his life history seminar (Cartwright & French, 1939; Polansky, 1941). By 1945, however, the newly renamed Journal of Personality had changed to re ect the interests of American personality psychologists. The new direction was signaled by the omission from the title of character, an older term preferred by many European psychologists (see Roback, 1927a). The proportion of studies of individuals declined sharply between the 1930s and the 1950s (Shermer, 1985). Even among clinical psychologists, the status of case studies remained marginal. Allport s retirement as editor of the Journal of Abnormal and Social Psychology was followed by another dramatic decrease in the number of studies of individuals published in the journal (Shermer, 1985). Commenting on a pioneering book of clinical case studies (Burton & Harris, 1947), Dollard noted that it relied heavily on test material and was not the much-needed book of illuminating case histories for the teacher of Abnormal Psychology (1948, p. 541). What Happened to Murray s Personological Concepts It seems clear that Murray s theory and methods, as originally developed in Explorations in Personality and later
The essential power of the method of types arises from the following theorem, which shows that the number of types is at most polynomial in n. Theorem 11.1.1 |Pn | (n + 1)|X | . (11.6)
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