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The dotted lines show where the scrollbars will appear, by default The name of the page is displayed here . . . . . . . . . . . . . . . . . . . . . . . . . . . . supplies were tenuous throughout most of our history and that individuals possessing genes that encouraged the collection of food and the storage of excess energy as fat would tend to survive better during periods of famine (Neel, 1962). These advantageous thrifty genes would be positively selected through thousands of generations; their persistence into modern and af uent societies, where food is readily and continuously available, will continue to promote the deposition of fat and hence obesity. Obesity shortens life expectancy, but most obese people survive into and beyond the reproductive years, so there is no selection pressure against the thrifty genes under present-day conditions. The thrifty gene hypothesis has dominated thinking for over 50 years, but has recently been challenged (Benyshek and Watson, 2006; Speakman, 2004, Speakman, 2007). It is argued that major famines are a comparatively recent phenomenon (since the spread of organized agriculture), and they are rare events (every 150 years, in most populations) and kill relatively few people. Consequently, famine might not have a suf ciently powerful or longlasting selection impact to cause the widespread acquisition of thrifty genes. Modern hunter-gatherers, such as the !kung san tribe from Cameroon do not become obese between periods of famine (Speakman, 2007). Moreover, the distribution of BMI in modern populations indicates that there exists a subgroup who remain lean despite the prevailing obesogenic environment (Flegal et al., 2002; Ogden et al., 2006). This begs the question as to why the intense positive selection for thrifty genes has somehow spared these individuals. Speakman (2007) has suggested a radical alternative, namely the release from predation hypothesis. This proposes that body weight ranges between a lower limit, imposed by the risk of starvation, and an upper limit that relates to the risk of being killed by predators. Ancient hominids such as Australopithecus (2 6 million years ago) lived among large predators, and overweight individuals might not have survived. The development of social behaviour, re and weapons is postulated to have removed the threat of predation and thus the ceiling on body weight when weight, freed from selection pressure, would be subject to random genetic drift. This hypothesis is supported by mathematical modelling of the distribution of BMI in modern populations following 2 million years of
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